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On initiation or discontinuation of guselkumab in patients who're obtaining concomitant CYP450 substrates, specially People with a narrow therapeutic index, consider monitoring for therapeutic effect.フェノバルビタールは甲状腺ホルモンの代謝を促進し、血中の甲状腺ホルモン濃度を低下させ、下垂体からの甲